Serene+
Daily support for better sleep, a calmer mood and a more resilient you.
Helps Support
Stress
Sleep
Wellbeing
Antioxidant
Mood
- Includes Affron®, an award-winning, high-quality patented variety of Spanish saffron, clinically studied for mood, sleep and stress support
- Contains Extramel®, a patented extract from a unique variety of French Cantaloupe melon, rich in antioxidants
- With essential organic lavender oil from France, known for its calming and relaxing properties
- Plus a natural form of magnesium harvested from the Irish Sea. Magnesium contributes to a reduction of tiredness and fatigue
Serene+ contains a blend of high-quality ingredients that each work on a different aspect of sleep, mood and stress. One capsule a day builds a consistent foundation to support a feeling of calm, better rest, and emotional resilience over time.
V Ve GF LF
| Ingredient | Per capsule | % NRV* |
|---|---|---|
| Organic Lavender 10% Essential Oil Powder | 100mg | N/A |
| Affron® Saffron Extract [Std to 3.5% Lepticrosalides] | 28mg | N/A |
| Extramel® Melon Concentrate | 10mg | N/A |
| Marine Magnesium, of which Magnesium |
170mg 56.25mg |
N/A 15% |
| Vitamin B2 (Riboflavin) | 0.21mg | 15% |
| Vitamin B6 (Pyridoxal-5-Phosphate) | 0.7mg | 50% |
| Vitamin B12 (Methylcobalamin) | 1.25µg | 50% |
| Pantothenic Acid (Vitamin B5) | 3mg | 50% |
* Nutrient Reference Value
What is Serene+?
Most sleep and mood supplements focus on one thing – a herb, a mineral, a vitamin. Serene+ takes a different approach. It combines four natural ingredients that each work on a different aspect of sleep, mood and stress – so rather than targeting one pathway, it supports the whole picture. One capsule a day, every day, builds a consistent baseline of calm, better rest and emotional resilience over time.
Why these ingredients?
Every ingredient in Serene+ is there for a specific, evidence-based reason. Affron® saffron extract is one of the most clinically researched botanicals for mood and sleep – with 7 human studies showing it supports positive emotional wellbeing, reduces occasional anxiety and improves sleep quality, partly by supporting your body's natural melatonin production.
Extramel® cantaloupe melon extract provides SuperOxide Dismutase – a natural antioxidant enzyme linked to mood and stress resilience. Organic lavender oil has been used for centuries to support relaxation and sleep onset. And marine magnesium with vitamins B6 and B2 underpin the psychological and cellular foundations that mood and sleep depend on.
Why does consistency matter?
Serene+ is not a sleep aid you reach for on bad nights. It works by building a daily foundation – supporting your body's natural rhythms and stress responses over weeks, not hours.
Clinical studies of Affron® show meaningful improvements in mood and sleep within four weeks of daily use. The longer you take it, the more established that foundation becomes. Think of it less like a remedy and more like a daily investment in how you feel.
Is Serene+ right for you?
Serene+ is for anyone looking for natural daily support for sleep, mood and stress – particularly if:
- You need help to switch off in the evening, or to calm your mind before sleep
- You're looking for support to manage stress, anxiety or occasional low mood
- You want a natural alternative to support your sleep and wellbeing
- You want a supplement backed by clinically studied ingredients – not simply herbal tradition
- You're looking for a gentle, daily supplement you can take consistently without side effects
Please note that Serene+ is a food supplement, not a medicine or substitute for prescribed treatment. If you are experiencing significant anxiety, depression or a diagnosed sleep disorder, please speak to your doctor.
"Sleep, mood and stress are deeply interconnected. That's why we formulated Serene+ to support all three together, helping your body build a stronger foundation for everyday calm and restful sleep."
Ingredient Highlights
Saffron has one of the strongest clinical evidence bases of any botanical ingredient for mood and sleep support. Affron® is a premium saffron extract derived from Spanish Crocus sativus stigmas and standardised to a precise quality standard that ensures consistency across every batch.
Human studies have shown Affron® helps alleviate occasional stress and anxiety, supports positive emotional wellbeing, and contributes to improved sleep quality. In a 12-week clinical study, 72% of participants taking Affron® experienced a significant improvement in emotional wellbeing (Lopresti A.L. et al., J Nutr, 2025). Uniquely, it also supports the body's natural production of melatonin – the hormone that regulates the sleep-wake cycle – making it particularly useful for those whose sleep is disrupted by stress or an overactive mind.
Extramel® is a cantaloupe melon (Cucumis melo) fruit juice concentrate rich in SuperOxide Dismutase (SOD) – one of the body's primary natural antioxidant enzymes.
SOD is found in every cell and plays a key role in protecting against oxidative stress. Research suggests that antioxidant-rich approaches may have a positive effect on mood, anxiety and stress resilience – and Extramel® provides a concentrated, bioavailable source of this naturally occurring enzyme that would be very difficult to obtain from diet alone. In a 12-week study, participants taking Extramel® experienced significantly decreased levels of perceived stress, including reduced irritability and increased mental focus (Carillon, J. et al, Nutrients, 2014).
Serene+ includes marine magnesium alongside four B vitamins, each chosen for a specific reason. Magnesium contributes to normal psychological function and the reduction of tiredness and fatigue. Vitamin B6 is provided as pyridoxal-5-phosphate – the active form your body can use straight away without having to convert – and contributes to normal psychological function and hormone regulation.
Vitamin B5 (pantothenic acid) supports normal energy metabolism and mental performance. Vitamin B12 is provided as methylcobalamin – the active form of B12 – and contributes to normal psychological function and the reduction of tiredness and fatigue. Vitamin B2 (riboflavin) helps protect cells from oxidative stress, working alongside Extramel®'s antioxidant action.
Together these nutrients provide a daily foundation for the psychological and physical resilience that your mood, sleep and stress management all depend on.
Saffron has one of the strongest clinical evidence bases of any botanical ingredient for mood and sleep support. Affron® is a premium saffron extract derived from Spanish Crocus sativus stigmas and standardised to a precise quality standard that ensures consistency across every batch.
Human studies have shown Affron® helps alleviate occasional stress and anxiety, supports positive emotional wellbeing, and contributes to improved sleep quality. In a 12-week clinical study, 72% of participants taking Affron® experienced a significant improvement in emotional wellbeing (Lopresti A.L. et al., J Nutr, 2025). Uniquely, it also supports the body's natural production of melatonin – the hormone that regulates the sleep-wake cycle – making it particularly useful for those whose sleep is disrupted by stress or an overactive mind.
Extramel® is a cantaloupe melon (Cucumis melo) fruit juice concentrate rich in SuperOxide Dismutase (SOD) – one of the body's primary natural antioxidant enzymes.
SOD is found in every cell and plays a key role in protecting against oxidative stress. Research suggests that antioxidant-rich approaches may have a positive effect on mood, anxiety and stress resilience – and Extramel® provides a concentrated, bioavailable source of this naturally occurring enzyme that would be very difficult to obtain from diet alone. In a 12-week study, participants taking Extramel® experienced significantly decreased levels of perceived stress, including reduced irritability and increased mental focus (Carillon, J. et al, Nutrients, 2014).
Serene+ includes marine magnesium alongside four B vitamins, each chosen for a specific reason. Magnesium contributes to normal psychological function and the reduction of tiredness and fatigue. Vitamin B6 is provided as pyridoxal-5-phosphate – the active form your body can use straight away without having to convert – and contributes to normal psychological function and hormone regulation.
Vitamin B5 (pantothenic acid) supports normal energy metabolism and mental performance. Vitamin B12 is provided as methylcobalamin – the active form of B12 – and contributes to normal psychological function and the reduction of tiredness and fatigue. Vitamin B2 (riboflavin) helps protect cells from oxidative stress, working alongside Extramel®'s antioxidant action.
Together these nutrients provide a daily foundation for the psychological and physical resilience that your mood, sleep and stress management all depend on.
Trusted by thousands
Samantha B
Helping me sleep better
Absolutely brilliant! It's helping me sleep better and has improved my mood overall. I Would definitely recommend this to anyone!
Shirley C
It helps me get off to sleep at night.
It helps me get off to sleep at night. Excellent. Ordered them for my Grandson.
Joan
My score from my garmin watch read 90/100,
The first night I took these tablets my score from my garmin watch read 90/100, excellent! Before my score has been poor 48 to 50. I'll continue with the tablets to see if it continues which would be great. So lovely yo get a good quality sleep. Very impressed!
Ann H
The best thing I have ever tried
This product is the best thing I have ever tried. i had radiation treatment a year ago .I could not sleep and my diabetes was all over the place..But since I've been taking serene my life has changed I'm so grateful to you all
FAQs
What is Serene+ and what does it contain?
Serene+ is a natural daily supplement formulated to support sleep quality, mood and stress resilience. Each capsule contains: Affron® – a Spanish saffron extract (Crocus sativus stigmas) standardised to 3.5% Lepticrosalides® by HPLC, clinically studied to support mood, reduce occasional stress and anxiety, and improve sleep quality; Extramel® – a cantaloupe melon fruit juice concentrate (Cucumis melo) rich in natural antioxidants linked to mood and stress resilience; organic lavender essential oil powder, traditionally used to support relaxation and sleep onset; marine magnesium for normal psychological function; vitamin B6 (as pyridoxal-5-phosphate, the active form) for normal psychological function and hormone regulation; vitamin B5 (pantothenic acid) for normal energy metabolism and mental performance; vitamin B12 (methylcobalamin, the active form) for normal psychological function and the reduction of tiredness; and riboflavin (B2) for protection of cells from oxidative stress. Serene+ is vegan, vegetarian, gluten-free and lactose-free.
What is Affron® and what does the research show?
Affron® is a premium, clinically studied saffron extract standardised to 3.5% Lepticrosalides® by HPLC. It is derived from Spanish saffron (Crocus sativus stigmas) – one of the most researched botanicals for mood and sleep support. Human clinical studies have shown Affron® supports positive emotional wellbeing, helps alleviate occasional stress and anxiety, and contributes to improved sleep quality. It also supports the body's natural production of melatonin – the hormone that regulates the sleep-wake cycle. In a 12-week clinical study, 72% of participants taking Affron® experienced a significant improvement in emotional wellbeing (Lopresti A.L. et al., J Nutr, 2025).
What is Extramel®?
Extramel® is a patented cantaloupe melon fruit juice concentrate (Cucumis melo), rich in SuperOxide Dismutase (SOD) – a natural antioxidant enzyme found in every cell of the body. SOD is one of the body's primary defences against oxidative stress, and research suggests that antioxidant-rich diets and supplements may have a positive effect on mood, anxiety and resilience to occasional stress. Extramel® provides a concentrated, bioavailable source of this naturally occurring enzyme. In a 12-week study, participants taking Extramel® experienced significantly decreased levels of perceived stress, including reduced irritability and increased mental focus (Carillon, J. et al, Nutrients, 2014).
Is Serene+ a medicine or a drug?
No. Serene+ is a food supplement, not a medicine or prescription drug. It contains natural ingredients – saffron extract, melon extract, lavender oil and magnesium – and is designed to support mood, sleep and stress resilience as part of a healthy lifestyle. It is not intended to diagnose, treat, cure or prevent any medical condition. If you are experiencing significant anxiety, depression or sleep disorders, please consult your doctor. Serene+ is not a substitute for prescribed medication.
How long does Serene+ take to work?
Many customers notice early improvements in mood and sleep quality within the first 2-4 weeks of consistent daily use. The Affron® saffron extract in Serene+ has been studied over 4-week periods in some clinical trials, with positive effects on mood and sleep observed within this timeframe. As with all food supplements, individual responses vary. FutureYou Cambridge recommend taking Serene+ consistently for at least 4-8 weeks to assess the full benefit.
What is the difference between Serene+ and Magnesium+ Advanced?
Both products contain magnesium and B vitamins, but they serve different primary purposes. Serene+ is specifically formulated for sleep, mood and stress support, with Affron® saffron extract and Extramel® melon extract as its key active ingredients. It provides marine magnesium alongside vitamins B2, B5, B6 and B12.
Magnesium+ Advanced uses Albion™ TRAACS™ magnesium bisglycinate buffered as its primary ingredient, providing 187.5mg of highly bioavailable magnesium per serving, and is designed to support energy and general magnesium replenishment. Serene+ is targeted to support sleep and mood, but the two supplements may be taken alongside one another for even more comprehensive support in our Wind Down Duo.
Can I take Serene+ with other FutureYou Cambridge supplements?
Yes – Serene+ can be taken alongside other FutureYou Cambridge supplements. Note that Advanced Multi+ also contains Affron® saffron, so if you are taking both, you will be getting a combined dose of this ingredient at safe levels.
Both Serene+ and Magnesium+ Advanced contain magnesium and B vitamins – and taken together they keep your daily intake comfortably within recommended levels. If you are taking any medication or have a medical condition, please consult your doctor or pharmacist before use.
Is Serene+ suitable for vegans?
Yes. Serene+ is vegan and vegetarian. The capsule shell is Hydroxypropyl Methylcellulose (HPMC) – a plant-derived material. All ingredients, including the Affron® saffron extract, Extramel® melon concentrate and organic lavender oil, are free from animal-derived components. Serene+ is also gluten-free and lactose-free.
When is the best time to take Serene+?
Serene+ can be taken at any time of day, but many customers find it most effective taken in the evening – approximately 1-2 hours before bed – to support the natural wind-down process and take advantage of the sleep-supporting properties of Affron® and lavender. One capsule per day is the recommended dose.
What's the difference between Serene+ and Magnesium+ Advanced?
1
2
52.25mg
187 mg
Marine
Bisglycinate
Affron, Extramel, Lavender, Vitamin B6, B12, B5, B2
Vitamin B1, B2, B6
Sleep & hormonal balance
Sleep & energy
When will I feel the benefits?
The natural ingredients begin working
Affron® saffron extract begins supporting your body's natural melatonin production and mood regulation from the first days of supplementation.
Extramel® provides daily antioxidant support through SuperOxide Dismutase. Marine magnesium begins contributing to normal psychological function and the reduction of tiredness.
Many customers notice early improvements in sleep quality and mood within the first four weeks – particularly a greater ease in winding down in the evening and a more consistent sense of calm during the day.
When will I feel the benefits?
More consistent results
As the ingredients build consistency in your system, the benefits become more reliable. Sleep onset – the time it takes to fall asleep – often improves during this period, alongside sleep quality and morning energy.
The mood-supporting effects of Affron®, shown in clinical studies, are often evident by this point. Occasional stress feels more manageable, and the cumulative antioxidant support of Extramel® is working alongside the B vitamins to protect against oxidative stress.
When will I feel the benefits?
Sustained mood, sleep and stress resilience
By month three, Serene+ is supporting a more established baseline of mood and sleep quality. The combination of Affron® for natural melatonin support, Extramel® for antioxidant resilience, lavender for relaxation, and magnesium for normal psychological function works as a daily support system for emotional and physical wellbeing.
Many customers at this stage report that they notice the difference most clearly when they miss a dose – a reliable sign that consistent supplementation is delivering measurable benefit.
Trusted by experts
Dr Max Gowland
Chief Scientific Officer
Max's passion is to help the over 50s stay healthy and stay active. As Chief Scientific Officer, Max works with the team to develop innovative products and is a regular presenter on QVC TV, helping to demystify supplements, health and nutrition.
Dr Miriam Ferrer
Head of Product Development
After her PhD, Miriam spent three years at the Medical Research Council Laboratory of Molecular Biology in Cambridge, before pivoting to supplement development. Her experience helps her to identify high-quality ingredients backed by rigorous research.
Dr Aidan Goggins
Nutritionist and author
Aidan is one of Europe's most influential nutrition experts and author of the award-winning book The Health Delusion and the international bestseller The Sirtfood Diet. He’s passionate about combining medicine with nutrition for better health outcomes.
Mr Peter Kirkpatrick
Medical advisor
Peter is a leading expert on strokes and arterial and vascular disease affecting the brain, and has published more than 200 studies. He is also president of the Cambridgeshire branch of Headway.
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Reviews
The views expressed below are the opinions of customers who have purchased this product. We do not endorse these views, nor should they be regarded as health claims or medical advice.
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